A Clinical Trial to Assess the Effect of Testosterone Treatment Combined With Dietary Restriction on Body Fat Mass and Muscle Function in Obese Men

Grant number: 1055305 | Funding period: 2013 - 2016

Completed

Abstract

Obesity, an increasing health and economic burden, is associated with lowered testosterone levels in men. While both dietary restriction and testosterone treatment reduce body fat, whether a combination of these two approaches achieves a more pronounced fat mass reduction is unknown. We will conduct a rigorous 12 month clinical trial of testosterone treatment in 150 obese men with a low testosterone level. All men will receive dietary intervention to induce and maintain weight loss

Related publications (7)

A body shape index (ABSI) reflects body composition changes in response to testosterone treatment in obese men

R Hoermann, MNT Fui, JC Krakauer, NY Krakauer, M Grossmann

2019-11-01

Background: Interventions such as testosterone treatment may change body composition and metabolic outcomes without substantial ch..

The effects of testosterone on body composition in obese men are not sustained after cessation of testosterone treatment

M Ng Tang Fui, R Hoermann, JD Zajac, M Grossmann

2017-10-01

Background: Testosterone treatment in obese dieting men augments the diet-associated loss of fat mass, but protects against loss o..

Symptomatic response to testosterone treatment in dieting obese men with low testosterone levels in a randomized, placebo-controlled clinical trial

M Ng Tang Fui, R Hoermann, LA Prendergast, JD Zajac, M Grossmann

2017-03-01

Background:Obese men commonly have reductions in circulating testosterone and report symptoms consistent with androgen deficiency...

Effect of testosterone treatment onadipokines and gut hormones in obese men on a hypocaloric diet

MNT Fui, R Hoermann, M Grossmann

2017-01-01

Context: In obese men with lowered testosterone levels, testosterone treatment augments dietassociated loss of body fat. Objective..

Testosterone treatment increases loss of body fat and prevents loss of lean mass in obese men with low testosterone levels on a hypocaloric diet: A randomized trial

Mark Ng Tang Fui, Luke A Prendergast, Philippe Dupuis, Manjri Raval, Boyd Strauss, Jeffrey Zajac, Mathis Grossmann

2017-01-01

Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: A randomised controlled trial

M Ng Tang Fui, LA Prendergast, P Dupuis, M Raval, BJ Strauss, JD Zajac, M Grossmann

2016-10-07

Background: Whether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. ..

Lowered testosterone in male obesity: Mechanisms, morbidity and management

MNT Fui, P Dupuis, M Grossmann

2014-03-01

With increasing modernization and urbanization of Asia, much of the future focus of the obesity epidemic will be in the Asian regi..

University of Melbourne Researchers

Mathis Grossmann